A convenient preparative method for 2–alkyl–γ–butyrolactones. (4th August 2014)

• Record Type: Journal Article
• Authors: Inaba, T.; Sakamoto, M.; Fujita, T.; Watanabe, S .
• Is Part Of: International journal of material & product technology. Volume 4:Number 2(1989)
• Page Start: 151
• Page End: 158
• Publication Date: 2014-08-04
• Subjects: 2–alkyl–&#947 -- –butyrolactones -- 2–acetyl–y–butyrolactones -- deacetylation -- alkylation; Manufacturing processes -- Periodicals; Materials -- Testing -- Periodicals; 620.11
• Languages: English
• ISSNs: 0268-1900

Abstract

Various 2–alkyl–γ–butyrolactones (IV) were prepared from 2–acetyl–γ–butyrolactone (I) via two steps: alkylation of 2–acetyl–γ–butyrolactone (I) followed by deacetylation. For example, 2–hexyl–γ–butyrolactone (IV; R = n–C6 H13 ) was prepared as follows: reaction of 2–acetyl–γ–butyrolactone (I) with n–hexyl bromide using sodium hydride as a base in dirnethylformamide gave 2 acetyl–2–hexyl–γ–butyrolactone (II; R = n–C6 H13 ) with 83% yield. Deacetylation of (II; R &#61# n–C6 H13 ) with sodium methoxide gave 2–hexyl–γ–butyrolactone (IV; R = n–C6 H13 ) with 85% yield.