Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy. Issue 46 (12th November 2018)

• Record Type: Journal Article
• Authors: Li, Zhigang; Lan, Xifa; Jiang, Xiaoxiao; Wang, Qiaoyun; Ma, Zhenhe; He, Zhonghai
• Is Part Of: Analytical methods. Volume 10:Issue 46(2018)
• Page Start: 5493
• Page End: 5498
• Publication Date: 2018-11-12
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c8ay01620h
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : The triglyceride (TG) to high density lipoprotein cholesterol ratio (TG/HDL-C) and the TG level itself have both been identified as a biomarker of insulin resistance, cardiovascular disease and a predictor for atherosclerosis. Abstract : The triglyceride (TG) to high density lipoprotein cholesterol ratio (TG/HDL-C) and the TG level itself have both been identified as a biomarker of insulin resistance, cardiovascular disease and a predictor for atherosclerosis. The aim of this study is to evaluate the feasibility of spectroscopy combined with partial least squares regression for quantitative analysis of TG and HDL-C in whole blood samples. Comparison of quantitative analysis results based on Fourier transform infrared spectra and Raman spectra was performed. The experimental results on whole blood samples demonstrate that the multi-component blood lipid quantitative analysis model based on FTIR-ATR spectroscopy has superior performance, and it is feasible to apply FTIR-ATR spectroscopy in point-of-care diagnostics of complex bio-fluids.