An aminoquinoline based biocompatible fluorescent and colourimetric pH sensor designed for cancer cell discrimination. (15th November 2018)

• Record Type: Journal Article
• Authors: Mandal, Jayanta; Ghorai, Pravat; Brandão, Paula; Pal, Kunal; Karmakar, Parimal; Saha, Amrita
• Is Part Of: New journal of chemistry. Volume 42:Number 24(2018)
• Page Start: 19818
• Page End: 19826
• Publication Date: 2018-11-15
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj04753g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A simple, low cost aminoquinoline based pH sensor, HL was prepared and it works at a low pH range.HL exhibits cell permeability and used as an effective tool for differentiating between normal and cancer cells. Abstract : Herein, we have reported a low cost simple aminoquinoline based pH sensorHL [HL = 2-methoxy-6-((quinolin-3-ylimino)methyl)phenol].HL acts as a potential low pH fluorometric as well as colourimetric pH probe. In acidic media it is colourless whereas, in basic media, it is yellow in colour.HL is thoroughly characterized by different spectroscopic techniques viz. UV-visible, fluorescence, 1 H and 13 C NMR spectroscopy along with ESI-MS and elemental analysis. We are successful in elucidating the X-ray crystal structure ofHL . Theoretical calculations such as DFT and TDDFT are also performed to support our experimental findings. The ability of this biocompatible pH sensor (HL ) to differentiate normal and cancer cells by alteration of pH will open new vistas for various biomedical applications.