A highly sensitive near-infrared fluorescent probe for the detection of hydrogen sulfide and its application in living cells and mice. (15th November 2018)

• Record Type: Journal Article
• Authors: Zhang, Xin; Sun, Runing; Duan, Guofeng; Zhou, Ziyan; Luo, Yanjun; Li, Wen; Zhang, Liying; Gu, Yueqing; Zha, Xiaoming
• Is Part Of: New journal of chemistry. Volume 42:Number 24(2018)
• Page Start: 19795
• Page End: 19800
• Publication Date: 2018-11-15
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj04824j
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Hydrogen sulfide (H2 S), an endogenous gaseous signalling molecule, has attracted attention in biochemical research. Abstract : Hydrogen sulfide (H2 S), an endogenous gaseous signalling molecule, has attracted attention in biochemical research. The detection of H2 S in living systems is essential for studying its functions. Although a variety of probes have been reported for the detection of cellular H2 S, the development of rapid, highly selective and sensitive near-infrared (NIR) probes for in vivo detection of H2 S still remains a challenging target. Herein we synthesized a near-infrared fluorescent probeCy-PBA, with good selectivity, high sensitivity (limit of detection = 21 nM) and rapid response time (<1.5 minutes). Importantly, Cy-PBA was successfully applied for fluorescence imaging of H2 S in living cells, mice and tissues with low cytotoxicity, indicating that it owns broad application prospects in the detection of H2 S in biological samples.