Phenotyping cardiomyopathy in adult zebrafish. (October 2018)

• Record Type: Journal Article
• Authors: Dvornikov, Alexey V.; de Tombe, Pieter P.; Xu, Xiaolei
• Is Part Of: Progress in biophysics and molecular biology. Volume 138(2018)
• Page Start: 116
• Page End: 125
• Publication Date: 2018-10
• Subjects: Cardiac remodeling -- Cardiomyopathy -- Sarcomere -- Zebrafish; CM cardiomyopathy -- DCM dilated cardiomyopathy -- EA early, E-wave velocity -- HCM hypertrophic cardiomyopathy -- ISO isoproterenol -- LDA length-dependent activation -- RCM restrictive cardiomyopathy -- SL sarcomere length -- Tmax isometric tension on maximal activation; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular Biology -- Periodicals; Biophysique -- Périodiques; Biochimie -- Périodiques; 571.4
• DOI: 10.1016/j.pbiomolbio.2018.05.013
• Languages: English
• ISSNs: 0079-6107

Abstract

Abstract: Hypertrophic cardiomyopathy (HCM) is usually manifested by increased myofilament Ca 2+ sensitivity, excessive contractility, and impaired relaxation. In contrast, dilated cardiomyopathy (DCM) originates from insufficient sarcomere contractility and reduced cardiac pump function, subsequently resulting in heart failure. The zebrafish has emerged as a new model of human cardiomyopathy with high-throughput screening, which will facilitate the discovery of novel genetic factors and the development of new therapies. Given the small hearts of zebrafish, better phenotyping tools are needed to discern different types of cardiomyopathy, such as HCM and DCM. This article reviews the existing models of cardiomyopathy, available morphologic and functional methods, and current understanding of the different types of cardiomyopathy in adult zebrafish.