Biocatalytic synthesis of lactones and lactams. Issue 23 (18th October 2018)

• Record Type: Journal Article
• Authors: Hollmann, Frank; Kara, Selin; Opperman, Diederik J.; Wang, Yonghua
• Is Part Of: Chemistry, an Asian journal. Volume 13:Issue 23(2018)
• Page Start: 3601
• Page End: 3610
• Publication Date: 2018-10-18
• Subjects: Baeyer–Villiger oxidation -- biocatalysis -- lactams -- lactones -- oxidative Lactonisation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201801180
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Cyclic esters and amides (lactones and lactams) are important active ingredients and polymer building blocks. In recent years, numerous biocatalytic methods for their preparation have been developed including enzymatic and chemoenzymatic Baeyer–Villiger oxidations, oxidative lactonisation of diols, and reductive lactonisation and lactamisation of ketoesters. The current state of the art of these methods is reviewed. Abstract : I want to ride my (bio)cycle : Lactones and lactams (cyclic esters and amides) are important synthons in various industries, especially as polymer building blocks. This review summarizes the current state of the art in (chemo)‐enzymatic routes to lactones and lactams, including Baeyer–Villiger oxidations, oxidative lactonisations of diols, and reductive cyclisations of ketoesters.