Physico-chemical evaluation of gymnemic acids nanocrystals. (8th October 2010)

• Record Type: Journal Article
• Authors: Ravichandran, R.
• Is Part Of: International journal of nanoparticles. Volume 3:Number 3(2010)
• Page Start: 280
• Page End: 296
• Publication Date: 2010-10-08
• Subjects: nanosuspension -- nanocrystals -- gymnemic acids -- physico-chemical properties -- nanotechnology -- particle size -- crystallinity -- kinetic solubility -- dissolution behaviour -- microcrystals -- absorption -- gastrointestinal tract -- bioavailability; Nanotechnology -- Periodicals; 620.505
• Languages: English
• ISSNs: 1753-2507

Abstract

Lyophilised gymnemic acids nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity, kinetic solubility and dissolution behaviour, and compared with microcrystals. The particle size was determined by photon correlation spectroscopy (PCS) and laser diffraction (LD). DSC and X-ray diffraction were used to study the crystalline state of gymnemic acids nanocrystals. The superior physicochemical properties observed with gymnemic acids nanocrystals over microcrystals should overcome the absorption problem in the gastrointestinal tract and increase the bioavailability.