A novel method to generate dynamic boundary conditions for airway CFD by mapping upper airway movement with non‐rigid registration of dynamic and static MRI. (14th September 2018)

• Record Type: Journal Article
• Authors: Bates, Alister J.; Schuh, Andreas; McConnell, Keith; Williams, Brynne M.; Lanier, J. Matthew; Willmering, Matthew M.; Woods, Jason C.; Fleck, Robert J.; Dumoulin, Charles L.; Amin, Raouf S.
• Is Part Of: International journal for numerical methods in biomedical engineering. Volume 34:Number 12(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-09-14
• Subjects: airways -- boundary conditions -- CFD -- magnetic resonance imaging -- movement -- non‐rigid registration -- obstructive sleep apnea; Biomedical engineering -- Periodicals; Imaging systems in medicine -- Periodicals; Numerical analysis -- Periodicals; Engineering mathematics -- Periodicals; 610.28
• DOI: 10.1002/cnm.3144
• Languages: English
• ISSNs: 2040-7939

Abstract

Abstract: Computational fluid dynamics (CFD) simulations of airflow in the human airways have the potential to provide a great deal of information that can aid clinicians in case management and surgical decision making, such as airway resistance, energy expenditure, airflow distribution, heat and moisture transfer, and particle deposition, as well as the change in each of these due to surgical interventions. However, the clinical relevance of CFD simulations has been limited to date, as previous models either did not incorporate neuromuscular motion or any motion at all. Many common airway pathologies, such as obstructive sleep apnea (OSA) and tracheomalacia, involve large movements of the structures surrounding the airway, such as the tongue and soft palate. Airway wall motion may be due to many factors including neuromuscular motion, internal aerodynamic forces, and external forces such as gravity. Therefore, to realistically model these airway diseases, a method is required to derive the airway wall motion, whatever the cause, and apply it as a boundary condition to CFD simulations. This paper presents and validates a novel method of capturing in vivo motion of airway walls from magnetic resonance images with high spatiotemporal resolution, through a novel combination of non‐rigid image, surface, and surface‐normal‐vector registration. Coupled with image‐synchronous pneumotachography, this technique provides the necessary boundary conditions for dynamic CFD simulations of breathing, allowing the effect of the airway's complex motion to be calculated for the first time, in both normal subjects and those with conditions such as OSA. Abstract : We present a new method to capture the motion of the upper and descending airways for use as dynamic boundary conditions for CFD simulations of respiratory airflow. Static and dynamic MRI are used to image the airway anatomy and motion, which then undergoes a combination of non‐rigid image, surface and surface‐normal‐vector registration to quantify this motion. This technique allows both passive and neuromuscular airway motion to be modeled and its effect on the patients breathing quantified for the first time.