Management of venous thromboembolism in patients with cancer. (15th October 2018)

• Record Type: Journal Article
• Authors: López‐Núñez, J. J.; Trujillo‐Santos, J.; Monreal, M.
• Is Part Of: Journal of thrombosis and haemostasis. Volume 16:Number 12(2018)
• Page Start: 2391
• Page End: 2396
• Publication Date: 2018-10-15
• Subjects: anticoagulant therapy -- bleeding -- cancer -- death -- recurrences -- venous thromboembolism; Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.14305
• Languages: English
• ISSNs: 1538-7933

Abstract

Summary: Current guidelines for anticoagulant therapy do not so far suggest any form of differentiated approach to cancer patients with venous thromboembolism (VTE). This review article provides an overview of the published literature in cancer patients with VTE, mostly using data from the RIETE registry. Our findings provide some insights into what factors may be used to guide physicians in adapting recommended anticoagulant regimens to the individual patient, as oncologists are increasingly doing with cancer treatments. For instance, patients presenting with deep vein thrombosis (DVT) alone might benefit from curtailing treatment intensity as anticoagulant therapy progresses. The site of cancer also needs to be considered. In patients with incidental PE or splanchnic vein thrombosis, we should be more cautious before prescribing anticoagulant therapy. The optimal duration of anticoagulant therapy is unknown.