Nitrosative DNA damage after sub-chronic exposure to silver nanoparticle induces stress nephrotoxicity in rat kidney. (2nd October 2018)

• Record Type: Journal Article
• Authors: Ranjbar, Akram; Firozian, Farzin; Soleimani Asl, Sara; Ghasemi, Hassan; Taheri Azandariani, Masumeh; Larki, Amir; Kheiripour, Nejat; Hosseini, Asieh; Naserabadi, Arman
• Is Part Of: Toxin reviews. Volume 37:Number 4(2018)
• Page Start: 327
• Page End: 333
• Publication Date: 2018-10-02
• Subjects: Silver nanoparticle -- oxidative stress -- rat -- kidney -- DNA damage; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2017.1386685
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: The current study was designed to find the effects of silver nanoparticles (AgNPs) against rat serum and kidney oxidative stress biomarkers. Urea, creatinine (Cr), total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), DNA damage, and nitric oxide (NO) were measured by spectrophotometric and immunoassay methods. Histopathological evaluation was performed using H&E staining. AgNP (250 ppm) caused a significant increase in kidney and serum oxidative stress biomarkers, serum concentrations of urea and Cr when compared to control group ( p < .05). Our findings suggest that antioxidant properties of AgNP are in dose-dependent manner.