Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer. Issue 96 (22nd October 2018)

• Record Type: Journal Article
• Authors: Zhang, Xianshuo; Zhang, Xiaolong; Sun, Lu; Liu, Fangjun; Wang, Mingqi; Peng, Jinlei; Wang, Yunfei; Ma, Liwei; Wang, Baoyan; Wei, Hua
• Is Part Of: Chemical communications. Volume 54:Issue 96(2018)
• Page Start: 13495
• Page End: 13498
• Publication Date: 2018-10-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc06685j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We reported the first preparation of triblock copolymer-based biocleavable shell cross-linked (SCL) hybrid micelles using a reducible silica monomer. Abstract : We report in this communication the first preparation of triblock copolymer-based biocleavable shell cross-linked (SCL) hybrid micelles using a reducible silica monomer that integrates a polymerizable methacrylate structure and in situ cross-linkers of silica precursors via a disulfide bond. The monomer developed herein offers a highly straightforward and robust strategy toward bioreducible silica-based hybrid nanoparticles for controlled drug release.