BSA-bioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy. Issue 46 (20th September 2018)

• Record Type: Journal Article
• Authors: Zhou, Benqing; Song, Jun; Wang, Meng; Wang, Xin; Wang, Jielin; Howard, Eric W.; Zhou, Feifan; Qu, Junle; Chen, Wei R.
• Is Part Of: Nanoscale. Volume 10:Issue 46(2018)
• Page Start: 21640
• Page End: 21647
• Publication Date: 2018-09-20
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c8nr05323e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : BSA-bioinspired, immunoadjuvant-loaded gold nanorods for synergetic cancer photothermal therapy and immunotherapy. Abstract : The development of therapeutic methods that can effectively delay tumor growth, inhibit tumor metastases, and protect the host from tumor recurrence still faces challenges. Nanoparticle-based combination therapy may provide an effective therapeutic strategy. Herein, we show that bovine serum albumin (BSA)-bioinspired gold nanorods (GNRs) were loaded with an immunoadjuvant for combined photothermal therapy (PTT) and immunotherapy for the treatment of melanoma. In this work, cetyltrimethylammonium bromide (CTAB)-coated GNRs were successively decorated with polyethylene glycol (PEG) and BSA, and loaded with an immunoadjuvant imiquimod (R837). The synthesized m PEG-GNRs@BSA/R837 nanocomplexes under near-infrared (NIR) irradiation could effectively kill tumors and trigger strong immune responses in treating metastatic melanoma in mice. Furthermore, the nanocomplex-based PTT prevented lung metastasis and induced a strong long-term antitumor immunity to protect the treated mice from tumor recurrence. The nanocomplex-based PTT in combination with immunotherapy may be potentially employed as an effective strategy for the treatment of melanoma and other metastatic cancers.