A facile approach to fabricate self-assembled magnetic nanotheranostics for drug delivery and imaging. Issue 46 (20th November 2018)

• Record Type: Journal Article
• Authors: Yuan, Ye; He, Yixuan; Bo, Ruonan; Ma, Zhao; Wang, Zhongling; Dong, Lijie; Lin, Tzu-yin; Xue, Xiangdong; Li, Yuanpei
• Is Part Of: Nanoscale. Volume 10:Issue 46(2018)
• Page Start: 21634
• Page End: 21639
• Publication Date: 2018-11-20
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c8nr05141k
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A novel and facile approach to perform surface modification of superparamagnetic iron oxide (SPIO) with large amounts of drug loaded was presented, which can not only improve the drug efficacy, but also enable to visualize themselves by magnetic resonance imaging (MRI). Abstract : Superparamagnetic iron oxide (SPIO) nanoparticles have been extensively employed for theranostic applications due to their good biocompatibility and excellent magnetic resonance imaging (MRI) properties. However, these particles typically require surface modification due to their hydrophobic surfaces caused by the oil-phase surfactants used in the fabrication and thus, the drug loading on their surface is usually limited. Here, we provided a novel and facile approach to conveniently perform surface modification of SPIO while simultaneously loading a large amount of drug. By synthesizing an amphiphilic irinotecan-based compound with a hydrophobic tail enabling insertion into the SPIO assembly, an excellent SPIO-based theranostic nanomedicine (SPIO@IR) was produced. SPIO@IR not only extensively improved the drug efficacy, but also allowed visualization by MRI in biological systems.