Acid-catalyzed synthesis of functionalized arylthio cyclopropane carbaldehydes and ketones. Issue 96 (16th November 2018)

• Record Type: Journal Article
• Authors: Porcu, Stefania; Luridiana, Alberto; Martis, Alberto; Frongia, Angelo; Sarais, Giorgia; Aitken, David J.; Boddaert, Thomas; Guillot, Regis; Secci, Francesco
• Is Part Of: Chemical communications. Volume 54:Issue 96(2018)
• Page Start: 13547
• Page End: 13550
• Publication Date: 2018-11-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc07571a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A general strategy for the synthesis of arylthio cyclopropyl carbaldehydes and ketones via acid catalysed arylthiol addition/ring contraction reaction sequence has been exploited. The procedure led to a wide panel of cyclopropyl carbonyl compounds in high yields and broad substrate scope. Abstract : A general strategy for the synthesis of arylthio cyclopropyl carbaldehydes and ketones via a Brønsted acid catalyzed arylthiol addition/ring contraction reaction sequence has been exploited. The procedure led to a wide panel of cyclopropyl carbaldehydes in generally high yields and with broad substrate scope. Mechanistic aspects and synthetic applications of this procedure were investigated.