Controlled synthesis of Fe3O4@ZIF-8 nanoparticles for drug delivery. Issue 46 (30th October 2018)

• Record Type: Journal Article
• Authors: Chen, Guihuan; Yu, Bing; Lu, Chenghao; Zhang, Haohao; Shen, Youqing; Cong, Hailin
• Is Part Of: CrystEngComm. Volume 20:Issue 46(2018)
• Page Start: 7486
• Page End: 7491
• Publication Date: 2018-10-30
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c8ce01302k
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : A novel one-pot synthetic method is introduced to produce Fe3 O4 @ZIF-8 NPs, which are proven to have potential applications as drug delivery models. Abstract : Encapsulating well-defined nanoparticles (NPs) into ZIF-8 to form core–shell structures not only can minimize the drawbacks and maximize the advantages of the disparate components but also may provide synergistic functionality. This work presents novel one-pot synthetic methods to produce Fe3 O4 @ZIF-8 NPs. Moreover, the morphology of Fe3 O4 @ZIF-8 NPs can be easily controlled by changing the synthesis conditions (time, temperature, and dosage). The as-obtained Fe3 O4 @ZIF-8 NPs have good dispersibility and a large specific surface area and they are proven to have potential applications as drug delivery models with good biocompatibility, high drug loading and good pH responsiveness.