Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Swendeman, Steven L.; Hla, Timothy
• Is Part Of: Trends in molecular medicine. Volume 24:Issue 12(2018)
• Page Start: 977
• Page End: 978
• Publication Date: 2018-12
• Subjects: eicosanoids -- leukotrienes -- M2-polarized macrophages -- pathological neovascularization -- age-related macular degeneration; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2018.10.003
• Languages: English
• ISSNs: 1471-4914

Abstract

Abstract : Sasaki and colleagues[1] ( JCI Insight 2018;3, e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular degeneration. This observation provides a novel mechanism by which an eicosanoid lipid mediator drives retinal vascular pathology and suggests a novel therapeutic target for proliferative retinal vascular diseases.