Controlled release of Berberine Chloride by electrospun core/shell PVP/PLCL fibrous membranes. (4th February 2010)

• Record Type: Journal Article
• Authors: Sun, Bin; Li, Shuo; Zhang, Hong; Li, Hua; Zhao, Chenguang; Yuan, Xiaoyan; Cui, Yuanlu
• Is Part Of: International journal of material & product technology. Volume 37:Number 3/4(2010)
• Page Start: 338
• Page End: 349
• Publication Date: 2010-02-04
• Subjects: coaxial electrospinning -- hot pressing -- berberine chloride -- controlled release -- wound dressing -- PVP-PLCL membranes -- wound healing -- skin repair -- biomedical engineering -- bioengineering -- drug control release; Manufacturing processes -- Periodicals; Materials -- Testing -- Periodicals; 620.11
• Languages: English
• ISSNs: 0268-1900

Abstract

Berberine chloride (BC) was loaded in the core/shell structured poly(vinyl pyrrolidone)/poly(L-lactide-co-ε-caprolactone) (PVP/PLCL) by coaxial electrospinning. After hot-press at 60°C, the mechanical properties of the electrospun PVP/PLCL membrane increased significantly. A burst release of BC from the electrospun PVP/PLCL fibres incubated in PBS at 37°C was found in 1 h and the cumulative released percentage of BC could exceed 90% at 72 h, significantly higher than that of BC encapsulated in PLCL. The drug-loaded electrospun PVP/PLCL membranes could potentially enhance wound healing in skin repair.