New insights into the pathophysiology of fasciculations in amyotrophic lateral sclerosis: An ultrasound study. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Vázquez-Costa, J.F.; Campins-Romeu, M.; Martínez-Payá, J.J.; Tembl, J.I.; del Baño-Aledo, M.E.; Ríos-Díaz, J.; Fornés-Ferrer, V.; Chumillas, M.J.; Sevilla, T
• Is Part Of: Clinical neurophysiology. Volume 129:Issue 12(2018:Dec.)
• Page Start: 2650
• Page End: 2657
• Publication Date: 2018-12
• Subjects: Amyotrophic lateral sclerosis -- Fasciculations -- Ultrasound -- Hyperexcitability -- Pathophysiology; LL lower limbs -- LMN lower motor neuron -- MRC muscle strength based on the medical research council scale -- MTh muscle thickness -- UL upper limbs -- UMN upper motor neuron -- US ultrasound; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2018.09.014
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Fasciculations are more frequent in proximal and cervical muscles and in upper limb onset patients. Fasciculations associate directly with BMI loss and upper motor neuron impairment and inversely with disability. Fasciculations increase with the initial lower motor neuron impairment but they decrease when it progresses. Abstract: Objective: To describe the fasciculation pattern in ALS and to analyse its clinical and pathophysiological significance. Methods: Ultrasound of 19 muscles was performed in 44 patients with a recent diagnosis (<90 days) of ALS. The number of fasciculations was recorded in each muscle and the muscle thickness and strength were additionally measured in limb muscles. A subgroup of patients were electromyographically assessed. Results: US was performed in 835 muscles and EMG was available in 263 muscles. US detected fasciculations more frequently than EMG. Fasciculations were widespread, especially in upper limbs onset patients and in the cervical region. Fasciculations' number inversely associated with ALSFR-R and body mass index (BMI) and directly with BMI loss and upper motor neuron (UMN) impairment. Our statistical model suggest that fasciculations increase with the initial lower motor neuron (LMN) degeneration, reach their peak when the muscle became mildly to moderately weak, decreasing afterwards with increasing muscle weakness and atrophy. Conclusions: Our study suggests that both UMN and LMN degeneration trigger fasciculations causing BMI loss. The degree of LMN impairment could account for differences in fasciculations' rates within and between muscles. Significance: In ALS, fasciculations could explain the link between hyperexcitability and BMI loss.