An Efficient, Facile Synthesis of Etoricoxib Substantially Free from Impurities: Isolation, Characterization and Synthesis of Novel Impurity. Issue 30 (23rd October 2017)

• Record Type: Journal Article
• Authors: Awasthi, Arun Kumar; Kumar, Brijesh; Aga, Mushtaq A.; Basha, Shaik Thaslim; Reddy, Cirandur Suresh; Kumar, Pramod
• Is Part Of: ChemistrySelect. Volume 2:Issue 30(2017)
• Page Start: 9722
• Page End: 9725
• Publication Date: 2017-10-23
• Subjects: COX-2 inhibitor -- Cyclocondensation -- Etoricoxib -- Impurities synthesis -- Vinamidinium salt; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701410
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A copper mediated efficient, facile synthesis of Etoricoxib from commercial available keto sulfone and vinamidinium salt was developed. This protocol with mild reaction conditions offered the product with >80% overall yield and remarkable quality. During process development an unknown impurity was observed, isolated, characterized (by NMR, mass and IR spectroscopy) and was identified as Pyrrole derivative. Abstract : A copper mediated efficient, facile synthesis of Etoricoxib from commercial available keto sulfone and vinamidinium salt was developed. This protocol with mild reaction conditions offered the product with >80% overall yield and remarkable quality. During process development an unknown impurity was observed, isolated, characterized (by NMR, mass and IR spectroscopy) and was identified as Pyrrole derivative.