The application of self-assembled nanostructures in peptide-based subunit vaccine development. (August 2017)

• Record Type: Journal Article
• Authors: Zhao, Guangzu; Chandrudu, Saranya; Skwarczynski, Mariusz; Toth, Istvan
• Is Part Of: European polymer journal. Volume 93(2017)
• Page Start: 670
• Page End: 681
• Publication Date: 2017-08
• Subjects: APC antigen-presenting cell -- BMA butyl methacrylate -- C16 2-(R/S)-hexadecanoic acid -- (C18)2 N, N-dioctadecyl succinamic acid -- CFA complete Freund's adjuvant -- CuAAC copper-catalyzed azide-alkyne cycloaddition -- DLS dynamic light scattering -- ELISA enzyme-linked immunosorbent assay -- FDA Food and Drug Administration -- GAS group A streptococcus -- HCV hepatitis C virus -- HIV human immunodeficiency virus -- HPV human papilloma virus -- IFA incomplete Freund's adjuvant -- IgG immunoglobulin G -- LCP lipid core peptide -- OVA ovalbumin -- PADRE pan DR epitope -- Pam2Cys dipalmitoyl-S-glyceryl cysteine -- Pam3Cys tripalmitoyl-S-glyceryl cysteine -- PbCSP Plasmodium berghei circumsporozoite protein -- PBS phosphate-buffered saline -- PDSMA pyridyl disulfide methacrylamide -- PEG-PPS poly(ethylene glycol)-stabilized poly(propylene sulfide) core nanoparticle -- SAP self-assembling polypeptide -- SARS severe acute respiratory syndrome -- TEM transmission electron microscopy -- TLR2 toll-like receptor 2 -- TLR4 toll-like receptor 4 -- TLR9 toll-like receptor 9 -- T-VEC talimogene laherparepvec -- VLP virus-like particle; Self-assembly -- Nanoparticle -- Nanofiber -- Vaccine -- Conjugation -- Polymer -- Lipopeptide; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2017.02.014
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Smaller polymer-peptide conjugates-based nanoparticles are often more immunogenic. Lipid-antigen conjugates-based nanoparticles can interact with immune receptors. Peptides with β-sheet conformation usually form nanofibers. α-Helical and random coil peptides tend to self-assemble into nanoparticles. Peptide-based nanostructures are usually poorer inducers of immune responses. Abstract: Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.