Learning from PD-1 Resistance: New Combination Strategies. Issue 6 (June 2016)

• Record Type: Journal Article
• Authors: Bu, Xia; Mahoney, Kathleen M.; Freeman, Gordon J.
• Is Part Of: Trends in molecular medicine. Volume 22:Issue 6(2016)
• Page Start: 448
• Page End: 451
• Publication Date: 2016-06
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2016.04.008
• Languages: English
• ISSNs: 1471-4914

Abstract

Abstract : Only a minority of cancer patients respond to anti PD-1 immunotherapy. A recent study demonstrates that PD-1 therapy-resistant melanoma patients present distinct signatures of upregulated genes involved in immunosuppression, angiogenesis, monocyte and macrophage chemotaxis, extracellular matrix remodeling, and epithelial–mesenchymal transition (EMT). Combination targeting of these pathways with PD-1 may help overcome PD-1 resistance, thus producing effective antitumor immunity.