'Mitotherapy' for Heart Failure. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Sanchis-Gomar, Fabian; Lippi, Giuseppe; Lucia, Alejandro
• Is Part Of: Trends in molecular medicine. Volume 22:Issue 4(2016)
• Page Start: 267
• Page End: 269
• Publication Date: 2016-04
• Subjects: heart -- pathway -- aging; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2016.02.007
• Languages: English
• ISSNs: 1471-4914

Abstract

Abstract : Abnormalities in mitochondrial dynamics along with those for the molecular mediators involved are presently being viewed with increased interest in the field of cardiovascular disease. Recent research highlights OPA1, a dynamin-like GTPase mediating mitochondrial fusion, as well as the 'mitoproteases' OMA1 and YME1L, as potential therapeutic targets against heart failure.