The 'Omics' of Voluntary Exercise: Systems Approaches to a Complex Phenotype. (December 2015)

• Record Type: Journal Article
• Authors: Kelly, Scott A.; Villena, Fernando Pardo-Manuel de; Pomp, Daniel
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 12(2015)
• Page Start: 673
• Page End: 675
• Publication Date: 2015-12
• Subjects: Collaborative Cross -- Diversity Outbred -- genomics -- proteomics -- transcriptomics -- wheel running; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2015.10.002
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : Predisposition to engage in exercise is highly variable and simultaneously influenced by the environment, complex genomics, and their interactions. Given the importance of exercise to health, understanding the underlying influences of variability is crucial. Here, we discuss murine systems approaches, focusing on 'omics', relevant to revealing the architecture of voluntary activity.