Diagnostic yield of ambulatory oesophageal studies on versus off proton pump inhibitors: a systematic review and meta-analysis. Issue 9 (November 2018)

• Record Type: Journal Article
• Authors: Ang, Daphne; Zheng, Qishi; Shi, Luming; Tack, Jan
• Is Part Of: United European Gastroenterology journal. Volume 6:Issue 9(2018)
• Page Start: 1294
• Page End: 1306
• Publication Date: 2018-11
• Subjects: Reflux evaluation -- gastroesophageal reflux disease -- acid reflux -- non-acid reflux; Gastroenterology -- Periodicals; Periodicals; 616.33005
• DOI: 10.1177/2050640618772787
• Languages: English
• ISSNs: 2050-6406

Abstract

Background: Patients with persistent gastroesophageal reflux disease symptoms despite proton pump inhibitors are increasingly encountered. It remains controversial if proton pump inhibitors should be stopped before functional oesophageal tests. Aim: This meta-analysis compares the positive yield of oesophageal studies performed off versus on proton pump inhibitors. Methods: Pubmed, Embase and the Cochrane Library were searched for eligible studies. Outcomes assessed were the number of subjects with: elevated oesophageal acid exposure time when studied off versus on proton pump inhibitors; positive symptom index (≥50%) and/or positive symptom association probability (≥95%) for acid reflux; and/or non-acid reflux events off versus on proton pump inhibitors. The random effects model was applied. Results: Fifteen studies ( n = 5033 individuals; 33% on proton pump inhibitors; 32% men; mean age 52.1 years) were analysed. Pooled risk ratio for the comparison of high oesophageal acid exposure time off versus on proton pump inhibitors was 2.16 (95% confidence interval (CI) 1.42–3.28). The risk ratio of a positive symptom index (acid reflux) was 2.64 (95% CI 1.52–4.57) and the risk ratio of a positive symptom association probability (acid reflux) was 2.94 (95% CI 2.31–3.74). Conversely, the risk ratio of a positive symptom index (non-acid reflux) was 0.96 (95% CI 0.49–1.88) and risk ratio of a positive symptom association probability (non-acid reflux) was 0.54 (95% CI 0.30–0.99). Conclusions: Oesophageal studies after proton pump inhibitor cessation improve the positive yield for acid reflux-related events but reduce the detection of symptomatic non-acid reflux events.