Spatiotemporal microstructural white matter changes in diffusion tensor imaging after transient focal ischemic stroke in rats. (16th February 2017)

• Record Type: Journal Article
• Authors: Jung, Won‐Beom; Han, Yong Hee; Chung, Julius Juhyun; Chae, Sun Young; Lee, Sung Hoon; Im, Geun Ho; Cha, JiHoon; Lee, Jung Hee
• Is Part Of: NMR in biomedicine. Volume 30:Number 6(2017:Jun.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-16
• Subjects: diffusion tensor imaging (DTI) -- stroke -- structural reorganization -- tract‐based spatial statistics (TBSS); Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.3704
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : Structural reorganization in white matter (WM) after stroke is a potential contributor to substitute or to newly establish the functional field on the injured brain in nature. Diffusion tensor imaging (DTI) is an imaging modality that can be used to evaluate damage and recovery within the brain. This method of imaging allows for in vivo assessment of the restricted movements of water molecules in WM and provides a detailed look at structural connectivity in the brain. For longitudinal DTI studies after a stroke, the conventional region of interest method and voxel‐based analysis are highly dependent on the user‐hypothesis and parameter settings for implementation. In contrast, tract‐based spatial statistics (TBSS) allows for reliable voxel‐wise analysis via the projection of diffusion‐derived parameters onto an alignment‐invariant WM skeleton. In this study, spatiotemporal WM changes were examined with DTI‐derived parameters (fractional anisotropy, FA; mean diffusivity, MD; axial diffusivity, DA; radial diffusivity, RD) using TBSS 2 h to 6 weeks after experimental focal ischemic stroke in rats ( N = 6). FA values remained unchanged 2–4 h after the stroke, followed by a continuous decrease in the ipsilesional hemisphere from 24 h to 2 weeks post‐stroke and gradual recovery from the ipsilesional corpus callosum to the external capsule until 6 weeks post‐stroke. In particular, the fibers in these areas were extended toward the striatum of the ischemic boundary region at 6 weeks on tractography. The alterations of the other parameters in the ipsilesional hemisphere showed patterns of a decrease at the early stage, a subsequent pseudo‐normalization of MD and DA, a rapid reduction of RD, and a progressive increase in MD, DA and RD with a decreased extent in the injured area at later stages. The findings of this study may reflect the ongoing processes on tissue damage and spontaneous recovery after stroke. Abstract : Spatiotemporal white matter changes were examined to reflect the ongoing processes for tissue damage and spontaneous recovery after stroke in rat with DTI‐derived parameters using tract‐based spatial statistics. Fractional anisotropy remained unchanged initially, followed by continuous decrease in the ipsilesional hemisphere at the acute stage and gradual recovery later. Alterations of the other parameters showed patterns of initial decrease, subsequent pseudo‐normalizations in mean and axial diffusivity, rapid reduction in radial diffusivity, and progressive increase in all of them with decreased areas later.