Single‐Scan 13C Diffusion‐Ordered NMR Spectroscopy of DNP‐Hyperpolarised Substrates. Issue 66 (22nd September 2017)

• Record Type: Journal Article
• Authors: Guduff, Ludmilla; Kurzbach, Dennis; van Heijenoort, Carine; Abergel, Daniel; Dumez, Jean‐Nicolas
• Is Part Of: Chemistry. Volume 23:Issue 66(2017)
• Page Start: 16722
• Page End: 16727
• Publication Date: 2017-09-22
• Subjects: diffusion-ordered spectroscopy (DOSY) -- dynamic nuclear polarisation -- hyperpolarisation -- NMR; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201703300
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Diffusion‐ordered NMR spectroscopy (DOSY) is a powerful approach for the analysis of molecular mixtures, yet its application range is limited by the relatively low sensitivity of NMR. We show here that spectrally resolved 13 C DOSY data can be collected, in a single scan, for substrates hyperpolarised by dissolution dynamic nuclear polarisation (D‐DNP), which provides signal enhancements of several orders of magnitude. For this we use a convection‐compensation pulse scheme, which we also analyse by numerical simulation. The proposed method further allows the acquisition of several consecutive DOSY spectra in a single D‐DNP experiment. Abstract : Taken in one shot : 13 C DOSY NMR spectra are obtained in a single scan from DNP‐hyperpolarised substrates, using a convection‐compensated spatial encoding of the diffusion dimension.