New Technology Mimics Physiologic Pulsatile Flow During Cardiopulmonary Bypass. Issue 2 (27th October 2017)

• Record Type: Journal Article
• Authors: Sunagawa, Gengo; Karimov, Jamshid H.; Dessoffy, Raymond; Byram, Nicole; Grady, Patrick; Sinkewich, Martin; Naber, Jeffrey P.; Vincent, Douglas; Okano, Shinji; Stewart, Robert D.; Sale, Shiva M.; Moazami, Nader; Fukamachi, Kiyotaka
• Is Part Of: Artificial organs. Volume 42:Issue 2(2018)
• Page Start: 231
• Page End: 235
• Publication Date: 2017-10-27
• Subjects: Cardiopulmonary bypass -- —Pulsatile flow -- —Animal model -- —Electromagnetic linear motor; Artificial organs -- Periodicals; 617.956
• DOI: 10.1111/aor.12986
• Languages: English
• ISSNs: 0160-564X

Abstract

Abstract: The Ventri Flo True Pulse Pump (Design Mentor, Inc., Pelham, NH, USA) is the first blood pump designed to mimic human arterial waveforms in a standard oxygenation circuit. Our aim was to demonstrate the feasibility and safety of this pump in preparation for future studies to determine possible clinical advantages. We studied four piglets (41.4–46.2 kg): three with an implanted Ventri Flo pulsatile pump and one with the nonpulsatile ROTAFLOW pump (MAQUET Holding B.V. & Co. KG, Rastatt, Germany) as a control. Hemodynamics was monitored during 6‐h cardiopulmonary bypass (CPB) support and for 2 h after weaning off CPB. The Ventri Flo demonstrated physiologic arterial waveforms with arterial pulse pressure of 24.6 ± 5.7 mm Hg. Pump flows (2.0 ± 0.1 L/min in ROTAFLOW; 1.9 ± 0.1 L/min in Ventri Flo ) and plasma free hemoglobin levels (27.9 ± 12.5 mg/dL in ROTAFLOW; 28.5 ± 14.2 mg/dL in Ventri Flo ) were also comparable, but systemic O2 extraction (as measured by arterial minus venous O2 saturation) registered slightly higher with the Ventri Flo (63.2 ± 6.9%) than the ROTAFLOW (55.4 ± 6.5%). Histological findings showed no evidence of ischemic changes or thromboembolism. This pilot study demonstrated that the Ventri Flo system generated pulsatile flow and maintained adequate perfusion of all organs during prolonged CPB.