2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Issue 5 (6th April 2017)

• Record Type: Journal Article
• Authors: Aggarwal, Rohit; Rider, Lisa G.; Ruperto, Nicolino; Bayat, Nastaran; Erman, Brian; Feldman, Brian M.; Oddis, Chester V.; Amato, Anthony A.; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; Fiorentino, David; Isenberg, David; Katz, James D.; Mammen, Andrew; de Visser, Marianne; Ytterberg, Steven R.; Lundberg, Ingrid E.; Chung, Lorinda; Danko, Katalin; García‐De la Torre, Ignacio; Song, Yeong Wook; Villa, Luca; Rinaldi, Mariangela; Rockette, Howard; Lachenbruch, Peter A.; Miller, Frederick W.; Vencovsky, Jiri
• Other Names: Rider Lisa G. investigator.; Ruperto Nicolino investigator.; Aggarwal Rohit investigator.; Miller Frederick W. investigator.; Vencovsky Jiri investigator.; Aggarwal Rohit investigator.; Erman Brian investigator.; Bayat Nastaran investigator.; Pistorio Angela investigator.; Huber Adam M. investigator.; Feldman Brian M. investigator.; Hansen Paul investigator.; Rockette Howard investigator.; Lachenbruch Peter A. investigator.; Ruperto Nicolino investigator.; Rider Lisa G. investigator.; Amato Anthony A. investigator.; Chinoy Hector investigator.; Christopher‐Stine Lisa investigator.; Chung Lorinda investigator.; Cooper Robert G. investigator.; Criscione‐Schreiber Lisa investigator.; Crofford Leslie investigator.; Cronin Mary E. investigator.; Dankó Katalin investigator.; Fiorentino David investigator.; García‐De la Torre Ignacio investigator.; Gordon Patrick investigator.; Hengstman Gerald investigator.; Katz James D. investigator.; Mammen Andrew investigator.; Marder Galina investigator.; McHugh Neil investigator.; Oddis Chester V. investigator.; Schiopu Elena investigator.; Selva‐O'Callaghan Albert investigator.; Wook Song Yeong investigator.; Vencovsky Jiri investigator.; Wolfe Gil investigator.; Wortmann Robert investigator.; Amato Anthony A. investigator.; Chinoy Hector investigator.; Chung Lorinda investigator.; Cooper Robert G. investigator.; Dankó Katalin investigator.; Fiorentino David investigator.; García‐De la Torre Ignacio investigator.; Gourley Mark investigator.; Lundberg Ingrid investigator.; Miller Frederick W. investigator.; Oddis Chester V. investigator.; Plotz Paul investigator.; Rider Lisa G. investigator.; Wook Song Yeong investigator.; Vencovsky Jiri investigator.; Aggarwal Rohit investigator.; Amato Anthony A. investigator.; Ascherman Dana investigator.; Barohn Richard investigator.; Benveniste Olivier investigator.; De Bleecker Jan investigator.; Callen Jeffrey investigator.; Charles‐Schoeman Christina investigator.; Chinoy Hector investigator.; Christopher‐Stine Lisa investigator.; Chung Lorinda investigator.; Cooper Robert G. investigator.; Crofford Leslie investigator.; Cronin Mary E. investigator.; Dankó Katalin investigator.; Danoff Sonye investigator.; Dastmalchi Maryam investigator.; de Visser Marianne investigator.; Dimachkie Mazen investigator.; DiMartino Steve investigator.; Dourmishev Lyubomir investigator.; Ernste Floranne investigator.; Fiorentino David investigator.; García‐De la Torre Ignacio investigator.; Gono Takahisa investigator.; Gordon Patrick investigator.; Gourley Mark investigator.; Isenberg David investigator.; Katsumata Yasuhiro investigator.; Katz James D. investigator.; Kissel John investigator.; Leff Richard L. investigator.; Levine Todd investigator.; Lundberg Ingrid investigator.; Mammen Andrew investigator.; Mann Herman investigator.; Marder Galina investigator.; Marie Isabelle investigator.; McHugh Neil investigator.; Merola Joseph investigator.; Miller Frederick W. investigator.; Oddis Chester V. investigator.; Olesinska Marzena investigator.; Olsen Nancy investigator.; Pipitone Nicolo investigator.; Ramchandren Sindhu investigator.; Rutkove Seward investigator.; Saketkoo Lesley Ann investigator.; Schiffenbauer Adam investigator.; Selva‐O'Callaghan Albert investigator.; Katsuyuki Shinjo Samuel investigator.; Shupak Rachel investigator.; Wook Song Yeong investigator.; Swierkocka Katarzyna investigator.; Vencovsky Jiri investigator.; Wanschitz Julia investigator.; Werth Victoria investigator.; Whitt Irene investigator.; Wortmann Robert investigator.; Ytterberg Steven R. investigator.; Aggarwal Rohit investigator.; Amato Anthony A. investigator.; Chinoy Hector investigator.; Christopher‐Stine Lisa investigator.; Chung Lorinda investigator.; Cooper Robert G. investigator.; Cronin Mary E. investigator.; Dankó Katalin investigator.; Dimachkie Mazen investigator.; DiMartino Steve investigator.; Fiorentino David investigator.; García‐De la Torre Ignacio investigator.; Gordon Patrick investigator.; Lundberg Ingrid investigator.; Mann Herman investigator.; Miller Frederick W. investigator.; Oddis Chester V. investigator.; Selva‐O'Callaghan Albert investigator.; Vencovsky Jiri investigator.; Werth Victoria investigator.; Wortmann Robert investigator.; Ytterberg Steven R. investigator.; Amato Anthony A. investigator.; Chinoy Hector investigator.; Cooper Robert G. investigator.; Dastmalchi Maryam investigator.; de Visser Marianne investigator.; Fiorentino David investigator.; Isenberg David investigator.; Katz James D. investigator.; Mammen Andrew investigator.; Oddis Chester V. investigator.; Vencovsky Jiri investigator.; Ytterberg Steven R. investigator.; Cimaz Rolando investigator.; Cuttica Rubén investigator.; Feitosa de Oliveira Sheila Knupp investigator.; Feldman Brian M. investigator.; Huber Adam M. investigator.; Lindsley Carol B. investigator.; Pilkington Clarissa investigator.; Punaro Marilynn investigator.; Ravelli Angelo investigator.; Reed Ann investigator.; Rouster‐Stevens Kelly investigator.; van Royen‐Kerkhof Annet investigator.;
• Is Part Of: Arthritis & rheumatology. Volume 69:Issue 5(2017)
• Page Start: 898
• Page End: 910
• Publication Date: 2017-04-06
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.40064
• Languages: English
• ISSNs: 2326-5191

Abstract

Abstract : Objective: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Methods: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Results: Consensus was reached for a conjoint analysis–based continuous model using absolute percent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement ( P < 0.001). Conclusion: The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute percent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.