Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center‐based Prospective Study. Issue 12 (15th September 2017)

• Record Type: Journal Article
• Authors: Masaoka, Hiroyuki; Matsuo, Keitaro; Sawada, Norie; Yamaji, Taiki; Goto, Atsushi; Shimazu, Taichi; Iwasaki, Motoki; Inoue, Manami; Eto, Masatoshi; Tsugane, Shoichiro
• Other Names: Tsugane S. investigator.; Sawada N. investigator.; Iwasaki M. investigator.; Sasazuki S. investigator.; Yamaji T. investigator.; Shimazu T. investigator.; Hanaoka T. investigator.; Ogata J. investigator.; Baba S. investigator.; Mannami T. investigator.; Okayama A. investigator.; Kokubo Y. investigator.; Miyakawa K. investigator.; Saito F. investigator.; Koizumi A. investigator.; Sano Y. investigator.; Hashimoto I. investigator.; Ikuta T. investigator.; Tanaba Y. investigator.; Sato H. investigator.; Roppongi Y. investigator.; Takashima T. investigator.; Suzuki H. investigator.; Miyajima Y. investigator.; Suzuki N. investigator.; Nagasawa S. investigator.; Furusugi Y. investigator.; Nagai N. investigator.; Ito Y. investigator.; Komatsu S. investigator.; Minamizono T. investigator.; Sanada H. investigator.; Hatayama Y. investigator.; Kobayashi F. investigator.; Uchino H. investigator.; Shirai Y. investigator.; Kondo T. investigator.; Sasaki R. investigator.; Watanabe Y. investigator.; Miyagawa Y. investigator.; Kobayashi Y. investigator.; Machida M. investigator.; Kobayashi K. investigator.; Tsukada M. investigator.; Kishimoto Y. investigator.; Takara E. investigator.; Fukuyama T. investigator.; Kinjo M. investigator.; Irei M. investigator.; Sakiyama H. investigator.; Imoto K. investigator.; Yazawa H. investigator.; Seo T. investigator.; Seiko A. investigator.; Ito F. investigator.; Shoji F. investigator.; Saito R. investigator.; Murata A. investigator.; Minato K. investigator.; Motegi K. investigator.; Fujieda T. investigator.; Yamato S. investigator.; Matsui K. investigator.; Abe T. investigator.; Katagiri M. investigator.; Suzuki M. investigator.; Matsui K. investigator.; Doi M. investigator.; Terao A. investigator.; Ishikawa Y. investigator.; Tagami T. investigator.; Sueta H. investigator.; Doi H. investigator.; Urata M. investigator.; Okamoto N. investigator.; Ide F. investigator.; Goto H. investigator.; Fujita R investigator.; Sakiyama H. investigator.; Onga N. investigator.; Takaesu H. investigator.; Uehara M. investigator.; Nakasone T. investigator.; Yamakawa M. investigator.; Horii F. investigator.; Asano I. investigator.; Yamaguchi H. investigator.; Aoki K. investigator.; Maruyama S. investigator.; Ichii M. investigator.; Takano M. investigator.; Tsubono Y. investigator.; Suzuki K. investigator.; Honda Y. investigator.; Yamagishi K. investigator.; Sakurai S. investigator.; Tsuchiya N. investigator.; Kabuto M. investigator.; Yamaguchi M. investigator.; Matsumura Y. investigator.; Sasaki S. investigator.; Watanabe S. investigator.; Akabane M. investigator.; Kadowaki T. investigator.; Inoue M. investigator.; Noda M. investigator.; Mizoue T. investigator.; Kawaguchi Y. investigator.; Takashima Y. investigator.; Yoshida Y. investigator.; Nakamura K. investigator.; Takachi R. investigator.; Ishihara J. investigator.; Matsushima S. investigator.; Natsukawa S. investigator.; Shimizu H. investigator.; Sugimura H. investigator.; Tominaga S. investigator.; Hamajima N. investigator.; Iso H. investigator.; Sobue T. investigator.; Iida M. investigator.; Ajiki W. investigator.; Ioka A. investigator.; Sato S. investigator.; Maruyama E. investigator.; Konishi M. investigator.; Okada K. investigator.; Saito I. investigator.; Yasuda N. investigator.; Kono S. investigator.; Akiba S. investigator.; Isobe T. investigator.; Sato Y. investigator.;
• Is Part Of: International journal of cancer. Volume 141:Issue 12(2017:Dec. 15)
• Page Start: 2480
• Page End: 2488
• Publication Date: 2017-09-15
• Subjects: acetaldehyde -- alcohol consumption -- bladder cancer -- flushing -- population‐based cohort study; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.31028
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : The association between alcohol consumption and bladder cancer risk has been insufficiently investigated in East Asian populations, who frequently have the inactive enzyme for metabolizing acetaldehyde. Given that acetaldehyde associated with alcohol consumption is assessed as a carcinogen, consideration of differences in acetaldehyde exposure would aid accuracy in assessing the bladder cancer risk associated with alcohol consumption. Here, we conducted a population‐based cohort study in Japan to examine this association, including information on the flushing response as a surrogate marker of the capacity of acetaldehyde metabolism. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariate Cox proportional hazard models. During follow up from 1990 through 2012 for the 95, 915 subjects (45, 649 men and 50, 266 women, aged 40–69 years), 354 men and 110 women were newly diagnosed with bladder cancer. No significant association between alcohol consumption and bladder cancer risk was observed in the overall analysis. Among male flushers, HRs were 1.04 (95% CI 0.70–1.54), 1.67 (1.16–2.42), 1.02 (0.62–1.67) and 0.63 (0.33–1.20) for alcohol consumption of 1–150, 151–300, 301–450, >450 g/week of pure ethanol compared with non‐drinkers and occasional drinkers, respectively, indicating an inverted U‐shaped association between alcohol consumption and bladder cancer risk. In contrast, no significant association was identified among male non‐flushers. The marginally significant interaction between alcohol consumption and the flushing response ( p for interaction = 0.083) may support our hypothesis that acetaldehyde derived from alcohol consumption is associated with bladder cancer risk. A prospective study considering polymorphisms of genes involved in acetaldehyde metabolism is warranted. Abstract : What's new? Many East Asians possess an inactive form of aldehyde dehydrogenase 2, the enzyme responsible for metabolizing acetaldehyde, a breakdown product of ethanol. Whether this diminished capacity for acetaldehyde metabolism affects bladder cancer risk associated with alcohol consumption remains unclear. In this population‐based cohort study in Japan, stratified analyses by facial flushing response, reflecting the capacity for acetaldehyde metabolism, show that moderate drinking (151–300 grams pure ethanol/week) is associated with elevated bladder cancer risk among flushers. Risk was not increased for heavy drinks or non‐flushers. The results suggest that acetaldehyde metabolized from alcohol influences bladder cancer development.