Cytotoxicity of Group 5 Transition Metal Ditellurides (MTe2; M=V, Nb, Ta). Issue 1 (28th November 2017)

• Record Type: Journal Article
• Authors: Chia, Hui Ling; Latiff, Naziah Mohamad; Sofer, Zdenĕk; Pumera, Martin
• Is Part Of: Chemistry. Volume 24:Issue 1(2018)
• Page Start: 206
• Page End: 211
• Publication Date: 2017-11-28
• Subjects: cytotoxicity -- ditellurides -- layered compounds -- transition metal dichalcogenides; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201704316
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Much research effort has been put in to study layered compounds with transition metal dichalcogenides (TMDs) being one of the most studied compounds. Due to their extraordinary properties such as excellent electrochemical properties, tuneable band gaps, and low shear resistance due to weak van der Waals interactions between layers, TMDs have been found to have wide applications such as electrocatalysts for hydrogen evolution reactions, supercapacitors, biosensors, field‐effect transistors (FETs), photovoltaics, and lubricant additives. In very recent years, Group 5 transition metal ditellurides have received an immense amount of research attention. However to date, little has been known of the potential toxicities posed by these materials. As such, we conducted the cytotoxicity study by incubating various concentrations of the Group 5 transition metal ditellurides (MTe2 ; M=V, Nb, Ta) with human lung carcinoma epithelial A549 cells for 24 hours and the remaining cell viabilities after treatment was measured. Our findings indicate that VTe2 is highly toxic whereas NbTe2 and TaTe2 are deemed to exhibit mild toxicities. This study constitutes an exemplary first step towards the understanding of the Group 5 transition metal ditellurides' toxicity effects in preparation for their possible future commercialisation. Abstract : A cytotoxicity study of Group 5 transition metal ditellurides with human lung epithelial carcinoma A549 cells by WST‐8 assay revealed that VTe2 is substantially more toxic than NbTe2 or TaTe2 .