Diversity‐Oriented Synthesis of Various Enantiopure Heterocycles by Coupling Organocatalysis with Multicomponent Reactions. Issue 45 (28th November 2017) - Caputo, Samantha
Abstract : Chiral, enantiopure 1, 3‐amino alcohols, obtained through an organocatalytic Mannich reaction, have been used as starting materials for a concise sequence involving a diastereoselective Ugi reaction followed by various types of SN 2 cyclization. In this way, different enantiopure heterocycles have been prepared, with both scaffold and decoration diversity (up to four diversity inputs). Abstract : Different enantiopure heterocycles have been prepared, exploring both scaffold and decoration diversity, by a sequence of an enantioselective Mannich reaction, a diastereoselective Ugi four‐component reaction, and various cyclizations.