Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance. (September 2015)
- Record Type:
- Journal Article
- Title:
- Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance. (September 2015)
- Main Title:
- Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance
- Authors:
- Dong, Ruijuan
Yuan, Jiuzhi
Wu, Shilong
Huang, Jian
Xu, Xiaotong
Wu, Zhaohua
Gao, Huiyuan - Abstract:
- Abstract : Graphical abstract: Twelve furanocassane derivatives, including six previously unreported were isolated from the seeds of Caesalpinia minax Hance. Neocaesalminin A (1 ) was found with an unusual A- seco -rearranged cassane skeleton. The inhibitory effect on NO production for all compounds was evaluated in vitro. Furanoditerpenes were responsible for this herb's anti-inflammation activity. Highlights: Cassane furanoditerpenes, six previously unreported were isolated from seeds of Caesalpinia minax Hance. Neocaesalminin A, a furanoditerpene, has an unusual A- seco -rearranged cassane skeleton. Inhibitory effects on NO production for all compounds were evaluated in vitro. Cassane furanoditerpenes were responsible for the Caesalpinia minax Hance anti-inflammation activity. Abstract: Cassane skeletons are rare in nature, but often possess valuable medicinal properties. A furanoditerpenoid with an unusual A- seco -rearranged cassane skeleton, neocaesalminin A, and five furanoditerpenoids were isolated from seeds of Caesalpinia minax Hance, along with six known cassane derivatives, 7- O -acetyl-bonducellpin C, caesalmin F, caesalmin C, ζ-caesalmin, caesalmin E1 and caesalpinin K. Compound structures were determined by spectroscopy (HR-ESI-MS, UV, IR, 1D NMR, 2D NMR), X-ray crystallography and quantum chemical computation of electronic circular dichroism). Three of the previously known compounds exhibited significant inhibition of nitric oxide production of RAW264.7Abstract : Graphical abstract: Twelve furanocassane derivatives, including six previously unreported were isolated from the seeds of Caesalpinia minax Hance. Neocaesalminin A (1 ) was found with an unusual A- seco -rearranged cassane skeleton. The inhibitory effect on NO production for all compounds was evaluated in vitro. Furanoditerpenes were responsible for this herb's anti-inflammation activity. Highlights: Cassane furanoditerpenes, six previously unreported were isolated from seeds of Caesalpinia minax Hance. Neocaesalminin A, a furanoditerpene, has an unusual A- seco -rearranged cassane skeleton. Inhibitory effects on NO production for all compounds were evaluated in vitro. Cassane furanoditerpenes were responsible for the Caesalpinia minax Hance anti-inflammation activity. Abstract: Cassane skeletons are rare in nature, but often possess valuable medicinal properties. A furanoditerpenoid with an unusual A- seco -rearranged cassane skeleton, neocaesalminin A, and five furanoditerpenoids were isolated from seeds of Caesalpinia minax Hance, along with six known cassane derivatives, 7- O -acetyl-bonducellpin C, caesalmin F, caesalmin C, ζ-caesalmin, caesalmin E1 and caesalpinin K. Compound structures were determined by spectroscopy (HR-ESI-MS, UV, IR, 1D NMR, 2D NMR), X-ray crystallography and quantum chemical computation of electronic circular dichroism). Three of the previously known compounds exhibited significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS). … (more)
- Is Part Of:
- Phytochemistry. Volume 117(2015:Sep.)
- Journal:
- Phytochemistry
- Issue:
- Volume 117(2015:Sep.)
- Issue Display:
- Volume 117 (2015)
- Year:
- 2015
- Volume:
- 117
- Issue Sort Value:
- 2015-0117-0000-0000
- Page Start:
- 325
- Page End:
- 331
- Publication Date:
- 2015-09
- Subjects:
- FUEMRDUPCPFBAQ-NFULFNSNSA-N -- KRHVJQKWELQGPY-QGEKGGCWSA-N -- OOUAFSXMWSCEGT-OEUDVJJISA-N -- JIKAOWSAQOJBMZ-DHUJPDJZSA-N -- KRTDSTYERVHJLI-SBRNPDNRSA-N -- OZMSPYFQLYZNFR-GWKQGQDASA-N
Caesalpinia minax Hance -- Caesalpinia -- A-seco-rearranged cassane -- Anti-inflammation activity -- Circular dichroism -- Conformation analysis
Botanical chemistry -- Periodicals
Biochemistry -- Periodicals
Botany -- Periodicals
Chimie végétale -- Périodiques
572.2 - Journal URLs:
- http://www.sciencedirect.com/science/journal/00319422 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.phytochem.2015.06.025 ↗
- Languages:
- English
- ISSNs:
- 0031-9422
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6489.800000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8815.xml