Concentrating carbohydrates before sleep improves feeding regulation and metabolic and inflammatory parameters in mice. (15th October 2015)

• Record Type: Journal Article
• Authors: Sofer, Sigal; Eliraz, Abraham; Madar, Zecharia; Froy, Oren
• Is Part Of: Molecular and cellular endocrinology. Volume 414(2015)
• Page Start: 29
• Page End: 41
• Publication Date: 2015-10-15
• Subjects: Food timing -- Leptin -- Ghrelin -- Adiponectin -- Feeding behavior -- Metabolic syndrome; ACC acetyl CoA carboxylase -- AdipoRS adiponectin receptors -- AgRP agouti-related protein -- ALT alanine aminotransferase -- AMPK AMP-activated protein kinase -- AST aspartate aminotransferase -- CCD concentrated carbohydrates diet -- DCD distributed carbohydrates diet -- GHSR growth hormone secretagogue receptor -- G6Pase glucose 6 phosphatase -- HFHS high fat high sucrose -- HOMA-IR homeostasis model assessment of insulin resistance -- IL-6 interleukin 6 -- iNOS inducible nitric oxide synthase -- MCH melanin concentrating hormone -- NPY neuropeptide Y -- ObRb leptin receptor b -- PEPCK phosphoenolpyruvate carboxykinase -- PGC-1α peroxisome proliferator-activated receptor gamma coactivator 1-alpha -- POMC pro-opiomelanocortin -- PPARS peroxisome proliferator-activated receptors -- TNFα tumor necrosis factor alpha -- UCP2 uncoupling protein 2 -- ZT zeitgeber time; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2015.06.032
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: New evidance highlights the importance of food timing. Recently, we showed that a low-calorie diet with carbohydrates eaten mostly at dinner changed diurnal hormone secretion and led to greater weight loss and improved metabolic status in obese people. Herein, we set out to test whether concentrated-carbohydrates diet (CCD), in which carbohydrates are fed only before sleep, leads to an improved metabolic status in mouse hypothalamus and peripheral tissues. Diet-induced obese mice were given concentrated or distributed carbohydrate diet for 6 weeks. Obese mice fed CCD ate 8.3% less, were 9.3% leaner and had 39.7% less fat mass. Leptin, ghrelin and adiponectin displayed altered secretion. In addition, these mice exhibited an improved biochemical and inflammatory status. In the hypothalamus, anorexigenic signals were up-regulated and orexigenic signals were down-regulated. In peripheral tissues, CCD promoted adiponectin signaling, repressed gluconeogenesis, enhanced lipid oxidation and lowered inflammation, thus ameliorating the major risk factors of obesity. Highlights: Carbohydrate-concentrated diet (CCD) before sleep leads to weight loss in mice. CCD leads to altered hormone secretion and up-regulation of satiety factors in mice. CCD promotes adiponectin signaling and low inflammation in mice.