Front Cover: Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery (Chem. Eur. J. 66/2017). Issue 66 (13th October 2017)

• Record Type: Journal Article
• Authors: Chalyk, Bohdan A.; Butko, Maryna V.; Yanshyna, Oksana O.; Gavrilenko, Konstantin S.; Druzhenko, Tetiana V.; Mykhailiuk, Pavel K.
• Is Part Of: Chemistry. Volume 23:Issue 66(2017)
• Page Start: 16691
• Page End: 16691
• Publication Date: 2017-10-13
• Subjects: azomethine ylides -- building blocks -- drug discovery -- pyrrolidines -- spirocycles; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201704329
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The cover picture shows novel building blocks for drug discovery—spirocyclic pyrrolidine. The synthesis starts from common four‐, five‐, six‐ and seven‐membered‐ring ketones and includes only two chemical steps. The key transformation is the reaction between electron‐deficient exocyclic alkenes and in situ generated N ‐benzyl azomethine ylide. The high potential of the developed method was demonstrated by the novel synthesis of the central core of the known antibacterial agents Sitafloxacin and Olamufloxacin. More information can be found in the Full Paper by P. K. Mykhailiuk et al. onpage 16782 .