Control of gene expression by novel metabolic intermediates. Issue 153 (September 2015)

• Record Type: Journal Article
• Authors: Gustafsson, Jan-Ake
• Is Part Of: Journal of steroid biochemistry and molecular biology. Issue 153(2015)
• Page Start: 102
• Page End: 104
• Publication Date: 2015-09
• Subjects: Ligand -- Nuclear receptor -- Steroid -- Bile acid -- Oxysterol; Steroid hormones -- Periodicals; Biochemistry -- Periodicals; Hormones -- Periodicals; Molecular Biology -- Periodicals; Hormones stéroïdes -- Périodiques; Steroid hormones; Periodicals; 572.579
• DOI: 10.1016/j.jsbmb.2015.04.008
• Languages: English
• ISSNs: 0960-0760

Abstract

Highlights: Ligands for nuclear receptors may have affinities in the micromolar range. Ligands for estrogen receptors may be found among androgens and oxysterols. Glucose may serve as a ligand for LXR. Steroid sulfates may be NR ligands. Intestinal microbial metabolites may be receptor ligands. Abstract: In view of the recent discoveries of novel nuclear receptors (NRs) whose ligands remain to be determined, metabolic intermediates may be considered as ligands for these receptors and undiscovered or overlooked intermediates may play important roles in regulating gene expression by activating or repressing the action of these nuclear receptors. This article is part of a Special Issue entitled 'Steroid Perspectives'.