Measuring Cerebral Hypoperfusion Induced by Hyperventilation Challenge With Intravoxel Incoherent Motion Magnetic Resonance Imaging in Healthy Volunteers. Issue 1 (January 2018)

• Record Type: Journal Article
• Authors: Pavilla, Aude; Arrigo, Alessandro; Mejdoubi, Mehdi; Duvauferrier, Régis; Gambarota, Giulio; Saint-Jalmes, Hervé
• Is Part Of: Journal of computer assisted tomography. Volume 42:Issue 1(2018)
• Publication Date: 2018-01
• Subjects: magnetic resonance imaging -- perfusion -- diffusion -- intravoxel incoherent motion -- hyperventilation -- hypocapnia; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000000640
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objectives: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. Materials and Methods: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver. Measurements were performed in normoventilation and HV conditions. Biexponential curve fitting was used to obtain the perfusion fraction ( f ), pseudodiffusion coefficient ( D *), and the product fD * in gray matter (GM) regions of interest (ROIs). Regional cerebral blood flow in the same ROIs was also assessed with arterial spin labeling. Results: The HV challenge led to a diminution of IVIM perfusion-related parameters, with a decrease of f and fD * in the cerebellum ( P = 0.03 for f ; P = 0.01 for fD *), thalamus GM ( P = 0.09 for f ; P = 0.01 for fD *), and lenticular nuclei ( P = 0.03 for f ; P = 0.02 for fD *). Mean GM cerebral blood flow (in mL/100 g tissue/min) measured with arterial spin labeling averaged over all ROIs also decreased (normoventilation: 42.7 ± 4.1 vs HV: 33.2 ± 2.2, P = 0.004) during the HV challenge. Conclusions: The optimized IVIM protocol proposed in the current study allows for measurements of cerebral hypoperfusion that might be of great interest for pathologies diagnosis such as ischemic stroke.