Sleep Duration and Quality as Related to Left Ventricular Structure and Function. Issue 1 (January 2018)

• Record Type: Journal Article
• Authors: Lee, Jae-Hon; Park, Sung Keun; Ryoo, Jae-Hong; Oh, Chang-Mo; Kang, Jeong Gyu; Mansur, Rodrigo B.; Alfonsi, Jeffrey E.; Lee, Yena; Shin, Sun-Han; McIntyre, Roger S.; Jung, Ju Young
• Is Part Of: Psychosomatic medicine. Volume 80:Issue 1(2018)
• Publication Date: 2018-01
• Subjects: hypertrophy -- left ventricular function -- remodeling -- sleep duration -- sleep quality -- A = peak velocities of the late phases of the mitral inflow -- a′ = peak late diastolic velocities measured at the level of the septal mitral valve annulus -- BMI = body mass index -- BP = blood pressure -- BSA = body surface area -- CV = cardiovascular -- DT = deceleration time -- E = peak velocities of the early phases of the mitral inflow -- EF = ejection fraction -- e′ = peak early diastolic velocities measured at the level of the septal mitral valve annulus -- HbA1c = serum hemoglobin A1c -- hsCRP = high-sensitivity C-reactive protein -- HEPA = health-enhancing physically active -- HDL = high-density lipoprotein -- IPAQ = International Physical Activity Questionnaire -- IVST = interventricular septum thickness -- LA = left atrium -- LDL = low-density lipoprotein -- LV = left ventricular -- LVDD = left ventricular diastolic dysfunction -- LVEDD = left ventricular end-diastolic diameter -- LVEDV = left ventricular end-diastolic volume -- LVESD = left ventricular end-systolic diameter -- LVESV = left ventricular end-systolic volume -- LVH = left ventricular hypertrophy -- LVMI = left ventricular mass index -- OR = odds ratio -- PSQI = the Pittsburgh Sleep Quality Index -- PW = pulsed wave -- PWT = posterior left ventricular wall thickness -- RWT = relative wall thickness -- SD = standard deviation -- SBP = systolic blood pressure; Medicine, Psychosomatic -- Periodicals; 616.0805
• DOI: 10.1097/PSY.0000000000000528
• Languages: English
• ISSNs: 0033-3174

Abstract

ABSTRACT: Objective: Inadequate sleep is associated with increased risk of cardiovascular events; however, the associations between sleep duration or quality and cardiac function or structure are not well understood. This cross-sectional study was conducted to investigate to what extent sleep duration and quality are associated with left ventricular (LV) diastolic dysfunction or structural deterioration. Methods: A total of 31, 598 healthy Korean adults who received echocardiography and completed the Pittsburg Sleep Quality Index were enrolled in this study. Participants were stratified into three groups by self-reported sleep duration (i.e., <7, 7–9, >9 hours) and into two groups by subjective sleep quality. Sleep duration was also assessed as a continuous variable. The odds ratios for impaired LV diastolic function, increased relative wall thickness, and LV hypertrophy (LVH) were compared between groups using multivariable logistic regression analyses. Results: After adjustment for confounding variables (e.g., age, smoking, body mass index), there was a statistically significant association between short sleep duration (<7 hours) and greater LVH (fully adjusted odds ratio = 1.32 [95% confidence interval {CI} = 1.02–1.73]). Short sleep duration was also significantly associated with greater LVH (0.87 per hour [95% CI = 0.78–0.98]) and increased relative wall thickness (0.92 [95% CI = 0.86–0.99]), but there was no significant association between sleep and LV diastolic function. Among individuals with normal sleep duration, poor quality of sleep was not associated with adverse cardiac measures. Conclusions: These results indicate that short sleep duration (<7 hours) is associated with unfavorable LV structural characteristics. The association of insufficient sleep with adverse cardiovascular health outcomes may be mediated in part by adverse changes in cardiac structure and function. Abstract : Supplemental digital content is available in the text.