0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction. Issue 5 (30th January 2018)

• Record Type: Journal Article
• Authors: Twerenbold, Raphael; Badertscher, Patrick; Boeddinghaus, Jasper; Nestelberger, Thomas; Wildi, Karin; Puelacher, Christian; Sabti, Zaid; Rubini Gimenez, Maria; Tschirky, Sandra; du Fay de Lavallaz, Jeanne; Kozhuharov, Nikola; Sazgary, Lorraine; Mueller, Deborah; Breidthardt, Tobias; Strebel, Ivo; Flores Widmer, Dayana; Shrestha, Samyut; Miró, Òscar; Martín-Sánchez, F. Javier; Morawiec, Beata; Parenica, Jiri; Geigy, Nicolas; Keller, Dagmar I.; Rentsch, Katharina; von Eckardstein, Arnold; Osswald, Stefan; Reichlin, Tobias; Mueller, Christian
• Is Part Of: Circulation. Volume 137:Issue 5(2018)
• Publication Date: 2018-01-30
• Subjects: 0/1-hour algorithm -- chronic kidney disease -- diagnosis of acute myocardial infarction -- high-sensitivity cardiac troponin -- renal dysfunction; Blood -- Circulation -- Periodicals; Cardiovascular system -- Periodicals; Cardiology -- Periodicals; Heart -- Diseases -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; 616.1
• DOI: 10.1161/CIRCULATIONAHA.117.028901
• Languages: English
• ISSNs: 0009-7322

Abstract

Abstract : Background: The European Society of Cardiology recommends a 0/1-hour algorithm for rapid rule-out and rule-in of non–ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective of renal function. Because patients with renal dysfunction (RD) frequently present with increased hs-cTn concentrations even in the absence of non–ST-segment elevation myocardial infarction, concern has been raised regarding the performance of the 0/1-hour algorithm in RD. Methods: In a prospective multicenter diagnostic study enrolling unselected patients presenting with suspected non–ST-segment elevation myocardial infarction to the emergency department, we assessed the diagnostic performance of the European Society of Cardiology 0/1-hour algorithm using hs-cTnT and hs-cTnI in patients with RD, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m 2, and compared it to patients with normal renal function. The final diagnosis was centrally adjudicated by 2 independent cardiologists using all available information, including cardiac imaging. Safety was quantified as sensitivity in the rule-out zone, accuracy as the specificity in the rule-in zone, and efficacy as the proportion of the overall cohort assigned to either rule-out or rule-in based on the 0- and 1-hour sample. Results: Among 3254 patients, RD was present in 487 patients (15%). The prevalence of non–ST-segment elevation myocardial infarction was substantially higher in patients with RD compared with patients with normal renal function (31% versus 13%, P <0.001). Using hs-cTnT, patients with RD had comparable sensitivity of rule-out (100.0% [95% confidence interval {CI}, 97.6–100.0] versus 99.2% [95% CI, 97.6–99.8]; P =0.559), lower specificity of rule-in (88.7% [95% CI, 84.8–91.9] versus 96.5% [95% CI, 95.7–97.2]; P <0.001), and lower overall efficacy (51% versus 81%, P <0.001), mainly driven by a much lower percentage of patients eligible for rule-out (18% versus 68%, P <0.001) compared with patients with normal renal function. Using hs-cTnI, patients with RD had comparable sensitivity of rule-out (98.6% [95% CI, 95.0–99.8] versus 98.5% [95% CI, 96.5–99.5]; P =1.0), lower specificity of rule-in (84.4% [95% CI, 79.9–88.3] versus 91.7% [95% CI, 90.5–92.9]; P <0.001), and lower overall efficacy (54% versus 76%, P <0.001; proportion ruled out, 18% versus 58%, P <0.001) compared with patients with normal renal function. Conclusions: In patients with RD, the safety of the European Society of Cardiology 0/1-hour algorithm is high, but specificity of rule-in and overall efficacy are decreased. Modifications of the rule-in and rule-out thresholds did not improve the safety or overall efficacy of the 0/1-hour algorithm. Clinical Trial Registration: URL:https://www.clinicaltrials.gov . Unique identifier: NCT00470587. Abstract : Supplemental Digital Content is available in the text.