Programming Bacteriophages by Swapping Their Specificity Determinants. Issue 12 (December 2015)

• Record Type: Journal Article
• Authors: Goren, Moran G.; Yosef, Ido; Qimron, Udi
• Is Part Of: Trends in microbiology. Volume 23:Issue 12(2015)
• Page Start: 744
• Page End: 746
• Publication Date: 2015-12
• Subjects: host-recognition ligand -- bacteriophage adsorption -- host-range expansion -- shaping bacterial microbiome; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2015.10.006
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.