Circadian Clocks and Metabolism: Implications for Microbiome and Aging. Issue 10 (October 2017)

• Record Type: Journal Article
• Authors: Paschos, Georgios K.; FitzGerald, Garret A.
• Is Part Of: Trends in genetics. Volume 33:Issue 10(2017)
• Page Start: 760
• Page End: 769
• Publication Date: 2017-10
• Subjects: circadian clock -- metabolism -- microbiome -- gender specificity -- aging; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2017.07.010
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract : The circadian clock directs many aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding, out of phase with the light schedule, may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender-specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome, and how they relate to aging. Trends: The circadian clock directs rhythms of cellular energy metabolism, while cellular energy status regulates circadian clock-driven transcription. Advances in metabolomics and metagenomics allow quantification of the enteral microbiota and permit the characterization of diurnal rhythms in microbiota abundance. Changes in cellular energy metabolism associated with aging may be driven by reduced amplitude of circadian rhythms in older age.