Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury. Issue 45 (October 2015)

• Record Type: Journal Article
• Authors: van de Looij, Yohan; Dean, Justin M.; Gunn, Alistair J.; Hüppi, Petra S.; Sizonenko, Stéphane V.
• Is Part Of: International journal of developmental neuroscience. Issue 45(2015:Oct.)
• Page Start: 29
• Page End: 38
• Publication Date: 2015-10
• Subjects: Mac macromolecules -- Asc ascorbate -- bhB beta-hydroxibutirate -- PCho phosphorylcholine -- Cr creatine -- PCr phosphocreatine -- GABA γ-aminobuttyric acid -- Glc glucose -- Glu glutamate -- Gln glutamine -- myo-Ins myo-inositol -- Lac lactate -- NAA N-acetylaspartate -- NAAG N-acetylaspartylglutamate -- PCr phosphocreatine -- PE phosphoethanolamine -- Tau taurine -- HI hypoxia-Ischemia -- LPS lipopolysaccharide -- MRI magnetic resonance imaging -- MRS magnetic resonance spectroscopy -- SNR signal-to-noise ratio -- TE echo time -- DTI diffusion tensor imaging -- QSM quantitative susceptibility mapping -- ADC apparent diffusion coefficient -- MD mean diffusivity -- D// parallel diffusivity -- D⊥ orthogonal diffusivity -- FA fractional anisotropy -- NODDI neurite orientation dispersion and density imaging -- ficvf intra-neurite volume fraction -- fiso cerebrospinal volume fraction -- fia intra-axonal volume fraction -- ODI orientation dispersion index -- MEMRI manganese enhanced magnetic resonance imaging -- DKI diffusion kurtosis imaging -- MK mean kurtosis -- K// parallel kurtosis -- K⊥ orthogonal kurtosis -- fMRI functional magnetic resonance imaging; Advanced magnetic resonance imaging -- Advanced magnetic resonance spectroscopy -- Animal models of perinatal brain injury -- Diffusion imaging -- Phase and susceptibility imaging -- Manganese enhanced magnetic resonance imaging; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1016/j.ijdevneu.2015.03.009
• Languages: English
• ISSNs: 0736-5748

Abstract

Highlights: This review presents advanced MRS and MRI techniques to assess the developing brain. High-field MRS quantifies metabolic changes during brain development and injury. High field susceptibility MR imaging leads to parameters sensitive to myelination. New diffusion imaging models lead to accurate parameters to probe microstructure. Abstract: Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are widely used in the field of brain development and perinatal brain injury. Due to technical progress the magnetic field strength (B0 ) of MR systems has continuously increased, favoring 1 H-MRS with quantification of up to 18 metabolites in the brain and short echo time (TE) MRI sequences including phase and susceptibility imaging. For longer TE techniques including diffusion imaging modalities, the benefits of higher B0 have not been clearly established. Nevertheless, progress has also been made in new advanced diffusion models that have been developed to enhance the accuracy and specificity of the derived diffusion parameters. In this review, we will describe the latest developments in MRS and MRI techniques, including high-field 1 H-MRS, phase and susceptibility imaging, and diffusion imaging, and discuss their application in the study of cerebral development and perinatal brain injury.