Genetic basis for relapse rate in multiple sclerosis: Association with LRP2 genetic variation. (November 2018)

• Record Type: Journal Article
• Authors: Hilven, Kelly; Vandebergh, Marijne; Smets, Ide; Mallants, Klara; Goris, An; Dubois, Bénédicte
• Is Part Of: Multiple sclerosis. Volume 24:Number 13(2018)
• Page Start: 1773
• Page End: 1775
• Publication Date: 2018-11
• Subjects: Multiple sclerosis -- genetics -- association -- heterogeneity -- prognosis -- relapses; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458517749894
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: In contrast to successes for multiple sclerosis (MS) susceptibility, the genetic basis for clinical heterogeneity remains largely unresolved. Objectives: We investigate the first reported genetic association with relapse rate. Methods: We genotyped variant rs12988804 in LRP2 in a homogeneous study population of 527 Belgian MS patients with 970 documented relapses. Results: The rs12988804*T allele is associated with a 1.16-fold increased hazard rate for a relapse occurring ( P = 0.0078) and a higher baseline relapse rate prior to immunomodulatory treatment ( P = 0.044). Conclusion: Variant rs12988804 in LRP2, the first example of a genome-wide significant association with relapse rate in MS, is replicated in an independent study.