Evaporation of decamethylcyclopentasiloxane (D5) from selected cosmetic products: Implications for consumer exposure modeling. (November 2015)

• Record Type: Journal Article
• Authors: Dudzina, Tatsiana; Garcia Hidalgo, Elena; von Goetz, Natalie; Bogdal, Christian; Hungerbuehler, Konrad
• Is Part Of: Environment international. Volume 84(2015:Nov.)
• Page Start: 55
• Page End: 63
• Publication Date: 2015-11
• Subjects: BP biphenyl -- C&PCPs cosmetics and personal care products -- D5 decamethylcyclopentasiloxane -- GC/FID gas chromatography with flame ionization detector -- HBSS Hank's Balanced Salt Solution -- HEPES 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid -- M4Q tetrakis (trimethylsiloxy)-silane -- PBPK model Physiologically Based Pharmacokinetic model -- SC Stratum Corneum -- SPE solid phase extraction -- THF tetrahydrofuran -- VOCs volatile organic compounds; Volatilization -- Cosmetic ingredients -- Formulation effect -- Porcine skin -- Stratum Corneum; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2015.07.013
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Consumer exposure to leave-on cosmetics and personal care products (C&PCPs) ingredients of low or moderate volatility is often assumed to occur primarily via dermal absorption. In reality they may volatilize from skin and represent a significant source for inhalation exposure. Often, evaporation rates of pure substances from inert surfaces are used as a surrogate for evaporation from more complex product matrices. Also the influence of partitioning to skin is neglected and the resulting inaccuracies are not known. In this paper we describe a novel approach for measuring chemical evaporation rates from C&PCPs under realistic consumer exposure conditions. Series of experiments were carried out in a custom-made ventilated chamber fitted with a vapor trap to study the disposition of a volatile cosmetic ingredient, decamethylcyclopentasiloxane (D5), after its topical application on either aluminum foil or porcine skin in vitro. Single doses were applied neat and in commercial deodorant and face cream formulations at normal room (23 °C) and skin temperature (32 °C). The condition-specific evaporation rates were determined as the chemical mass loss per unit surface area at different time intervals over 1–1.25 h post-dose. Product weight loss was monitored gravimetrically and the residual D5 concentrations were analyzed with GC/FID. The release of D5 from exposed surfaces of aluminum occurred very fast with mean rates of 0.029 mg cm − 2 min − 1 and 0.060 mg cm − 2 min − 1 at 23 °C and 32 °C, respectively. Statistical analysis of experimental data confirmed a significant effect of cosmetic formulations on the evaporation of D5 with the largest effect (2-fold decrease of the evaporation rate) observed for the neat face cream pair at 32 °C. The developed approach explicitly considers the initial penetration and evaporation of a substance from the Stratum Corneum and has the potential for application in dermal exposure modeling, product emission tests and the formulation of C&PCPs. Highlights: Realistic evaporation rates from finite doses of D5 are derived experimentally (81). Product ingredient interactions have a significant effect on D5 evaporation (79). Volatilization of D5 from skin must be considered in aggregate consumer exposure modeling (91).