Circulating Candidate Biomarkers in Giant Cell Tumors of Bone. Issue 6 (28th August 2018)
- Record Type:
- Journal Article
- Title:
- Circulating Candidate Biomarkers in Giant Cell Tumors of Bone. Issue 6 (28th August 2018)
- Main Title:
- Circulating Candidate Biomarkers in Giant Cell Tumors of Bone
- Authors:
- Conti, Amalia
Luchini, Alessandra
Benassi, Maria Serena
Magagnoli, Giovanna
Pierini, Michela
Piccinni‐Leopardi, Martina
Quattrini, Irene
Pollino, Serena
Picci, Piero
Liotta, Lance A.
Pazzaglia, Laura - Abstract:
- Abstract : Purpose: Approximately 5% of giant cell tumors (GCT) of bone develop pulmonary metastases. Although many biomarkers have been proposed, identification of circulating low abundance molecules may be useful to predict malignant progression. Experimental design: The hydrogel nanoparticle technique followed by MS was used to detect low molecular weight serum proteins or protein fragments in serum of 20 GCT patients with different clinical course and in ten healthy sera used as control. The most representative low‐abundant de novo or differentially abundant proteins were submitted to String database that recognized interconnected activated pathways including protein activation cascade, wound healing, cell‐substrate adhesion, and response to stress. Statistics were performed for identification of candidate prognostic factors. Results: Proteome cluster analysis separated metastasis‐free from metastatic GCT patients in two well‐defined groups where serum levels of signaling transduction mediators and regulators of kinase activity presented a high discriminatory power. Increased expression of proteins STAT5B, GRB2, and OXSR1 was related to a higher probability of metastasis. Multivariate analysis demonstrated that tumor grade and STAT5B were independent prognostic factors. Conclusions and clinical relevance: By using a noninvasive technique, we identified differentially abundant serum candidate biomarkers, also providing prognostic information in patients with GCT of bone.
- Is Part Of:
- Proteomics. Volume 12:Issue 6(2018)
- Journal:
- Proteomics
- Issue:
- Volume 12:Issue 6(2018)
- Issue Display:
- Volume 12, Issue 6 (2018)
- Year:
- 2018
- Volume:
- 12
- Issue:
- 6
- Issue Sort Value:
- 2018-0012-0006-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2018-08-28
- Subjects:
- MS -- metastasis -- nanoparticles -- prognostic biomarkers -- serum proteins
Proteomics -- Periodicals
572.605 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1862-8354 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/prca.201800041 ↗
- Languages:
- English
- ISSNs:
- 1862-8346
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6936.178500
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8778.xml