5‐hydroxymethylfurfural‐ and fluorescein‐fused fluorescence probe of mast cells (RBL‐2H3): Synthesis, photophysical properties, and bioimaging. (26th August 2018)

• Record Type: Journal Article
• Authors: Huang, Limin; Wei, Di; Wu, Zibo; Hou, Yajing; Xie, Yitong; Liu, Zhenru; Wang, Cheng; Che, Delu; Lei, Yibo; He, Huaizhen
• Is Part Of: Chemical biology & drug design. Volume 92:Number 6(2018)
• Page Start: 1963
• Page End: 1971
• Publication Date: 2018-08-26
• Subjects: bioimaging -- Fluo‐HMF -- fluorescent probe -- RBL‐2H3 cells -- theoretical calculation; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.13367
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract: A fluorescent probe (Fluo‐ HMF ) was developed via introduction of a furfural moiety into the fluorescein molecular skeleton, aiming at specially labeling cell membrane of mast cells. To illustrate its specificity, we designed and synthesized a series of fluorescent compounds based on fluorescein molecular skeleton. The fluorescent properties ofFluo‐ HMF were investigated, which were in accordance with theoretical calculations. Compared with other fluorescein derivatives, Fluo‐ HMF could specially label RBL‐2H3 cells. The results suggested thatFluo‐ HMF could be used as a fluorescent probe for bioimaging on some related research of allergic mechanism. Abstract : In this study, a fluorescent probe (Fluo‐ HMF ) based on the fluorescein molecular skeleton was prepared, which could specially label cell membrane of RBL‐2H3 cells.