Full gene HLA class I sequences of 79 novel and 519 mostly uncommon alleles from a large United States registry population. (20th September 2018)

• Record Type: Journal Article
• Authors: Lazaro, Ana; Hou, Lihua; Tu, Bin; Masaberg, Carly; Enriquez, Elizabeth; Gerfen, Jennifer; Kariyawasam, Kanthi; Persaud, Misti; Qin, Xihan; Simbulan, Dannah; Xiao, Yi; Xun, Lisa; Yang, Ruyan; Ng, Jennifer; Hurley, Carolyn K.
• Is Part Of: HLA. Volume 92:Number 5(2018)
• Page Start: 304
• Page End: 309
• Publication Date: 2018-09-20
• Subjects: hematopoietic stem cell transplantation -- histocompatibility testing -- HLAs -- polymorphism, genetic -- sequence analysis, DNA; Immunogenetics -- Periodicals; Antigens -- Periodicals; HLA histocompatibility antigens -- Periodicals; 571.9645
• DOI: 10.1111/tan.13377
• Languages: English
• ISSNs: 2059-2302

Abstract

Abstract : HLA class I assignments were obtained at single genotype, G‐level resolution from 98 855 volunteers for an unrelated donor registry in the United States. In spite of the diverse ancestry of the volunteers, over 99% of the assignments at each locus are common. Within this population, 52 novel alleles differing in exons 2 and 3 are identified and characterized. Previously reported alleles with incomplete sequences in the IPD‐IMGT/HLA database ( n = 519) were selected for full gene sequencing and, from this sampling, another 27 novel alleles are described.