The association between the NAT2 genetic polymorphisms and risk of DILI during anti‐TB treatment: a systematic review and meta‐analysis. (3rd October 2018)

• Record Type: Journal Article
• Authors: Zhang, Min; Wang, Shuqiang; Wilffert, Bob; Tong, Rongsheng; van Soolingen, Dick; van den Hof, Susan; Alffenaar, Jan‐Willem
• Is Part Of: British journal of clinical pharmacology. Volume 84:Number 12(2018)
• Page Start: 2747
• Page End: 2760
• Publication Date: 2018-10-03
• Subjects: antituberculosis drug‐induced liver injury -- meta‐analysis -- NAT2 -- polymorphism; Pharmacology -- Periodicals; Drugs -- Periodicals; 615.1
• DOI: 10.1111/bcp.13722
• Languages: English
• ISSNs: 0306-5251

Abstract

Abstract : Aims: The aim of this study is to evaluate the potential association between N ‐acetyltransferase type 2 ( NAT2 ) polymorphisms and drug‐induced liver injury during anti‐TB treatment (AT‐DILI). Methods: We conducted a systematic review and performed a meta‐analysis to clarify the role of NAT2 polymorphism in AT‐DILI. PubMed, Medline and EMBASE databases were searched for studies published in English to December 31, 2017, on the association between the NAT2 polymorphism and AT‐DILI risk. Outcomes were pooled with random‐effects meta‐analysis. Details were registered in the PROSPERO register (number: CRD42016051722). Results: Thirty‐seven studies involving 1527 cases and 7184 controls were included in this meta‐analysis. The overall odds ratio (OR) of AT‐DILI associated with NAT2 slow acetylator phenotype was 3.15 (95% CI 2.58–3.84, I 2 = 51.3%, P = 0.000). The OR varied between different ethnic populations, ranging from 6.42 (95% CI 2.41–17.10, I 2 = 2.3%) for the West Asian population to 2.32 (95% CI 0.58–9.24, I 2 = 80.3%) for the European population. Within the slow NAT2 genotype, variation was also observed; NAT2*6/*7 was associated with the highest risk of AT‐DILI (OR = 1.68, 95% CI 1.09–2.59) compared to the other slow NAT2 acetylators combined. Conclusions: NAT2 slow acetylation was observed to increase the risk of AT‐DILI in tuberculosis patients. Our results support the hypothesis that the slow NAT2 genotype is a risk factor for AT‐DILI.