Essential oils from Tithonia diversifolia display potent anti-oedematogenic effects and inhibit acid production by cariogenic bacteria. Issue 1 (2nd January 2019)

• Record Type: Journal Article
• Authors: Sousa, Ingrid Pontes; Chagas-Paula, Daniela Aparecida; Tiossi, Renata Fabiane Jorge; Silva, Eliane de Oliveira; Miranda, Mariza Abreu; de Oliveira, Rejane Barbosa; Spadaro, Augusto César Cropanese; Bastos, Jairo Kenupp; Furtado, Niege Araçari Jacometti Cardoso; Da Costa, Fernando Batista
• Is Part Of: Journal of essential oil research. Volume 31:Issue 1(2019)
• Page Start: 43
• Page End: 52
• Publication Date: 2019-01-02
• Subjects: Tithonia diversifolia -- essential oil -- anti-inflammatory -- antibacterial -- cytotoxicity; Essences and essential oils -- Periodicals; Oils, Volatile -- Periodicals; Plant Oils -- Periodicals; 547.71
• DOI: 10.1080/10412905.2018.1500315
• Languages: English
• ISSNs: 1041-2905

Abstract

ABSTRACT: Tithonia diversifolia is an invasive shrub found in the tropical regions. The aim of this study was to investigate the chemical composition as well as anti-inflammatory and antibacterial activities of the essential oils from leaves (EOL) and inflorescences (EOI) of T. diversifolia . The essential oils (EOs) were analysed by gas chromatography with flame ionization detector and coupled with mass spectrometry. EOL and EOI are mainly composed of α -pinene and β -pinene. Both EOL and EOI displayed potent anti-oedematogenic properties at concentrations starting at 0.5 and 2.5% (v/v), respectively. Similar to non-steroidal anti-inflammatory drugs, both EOs inhibited oedema but did not inhibit cellular recruitment. EOI displayed more potent antimicrobial activity against cariogenic microorganisms than EOL. Both EOs significantly inhibited the production of acids by Streptococcus mutans at concentrations that were nontoxic to human gingival fibroblasts (concentrations from 25 to 125 µg/mL for EOL and from 25 to 250 µg/mL for EOI).