Catalyst free, C-3 functionalization of imidazo[1, 2-a]pyridines to rapidly access new chemical space for drug discovery efforts. Issue 92 (30th October 2018)

• Record Type: Journal Article
• Authors: Gunaganti, Naresh; Kharbanda, Anupreet; Lakkaniga, Naga Rajiv; Zhang, Lingtian; Cooper, Rose; Li, Hong-yu; Frett, Brendan
• Is Part Of: Chemical communications. Volume 54:Issue 92(2018)
• Page Start: 12954
• Page End: 12957
• Publication Date: 2018-10-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc07063f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Development of a multicomponent reaction to functionalize the C-3 position of imidazo[1, 2- a ]pyridines via a three component, decarboxylation protocol. Abstract : Multicomponent reactions (MCRs) are robust tools for the rapid synthesis of complex, small molecule libraries for use in drug discovery and development. By utilizing MCR chemistry, we developed a protocol to functionalize the C-3 position of imidazo[1, 2- a ]pyridine through a three component, decarboxylation reaction involving imidazo[1, 2- a ]pyridine, glyoxalic acid, and boronic acid.