Heart rate reduction after ivabradine might be associated with reverse electrical remodeling in patients with cardiomyopathy and left bundle branch block. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Kučerová, Andrea; Doškář, Petr; Dujka, Libor; Lekešová, Veronika; Volf, Petr; Koščová, Katarina; Neužil, Petr; Málek, Filip
• Is Part Of: Journal of international medical research. Volume 46:Issue 11(2018)
• Page Start: 4825
• Page End: 4828
• Publication Date: 2018-11
• Subjects: Electrical remodeling -- ivabradine -- left bundle branch block -- cardiomyopathy -- chronic heart failure -- intraventricular conduction; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060518799566
• Languages: English
• ISSNs: 0300-0605

Abstract

Left bundle branch block increases the risk of death in patients with chronic heart failure. We herein report four clinical cases of patients with chronic heart failure caused by nonischemic cardiomyopathy with left bundle branch block that occurred when adding ivabradine to optimal medical therapy, resulting in reverse electrical and mechanical remodeling. This phenomenon might be explained by the effect of ivabradine on reverse remodeling of the left ventricle with improvement of intraventricular conduction.